Hyperlactataemia in Phenformin-treated Diabetics
نویسندگان
چکیده
منابع مشابه
Clinical experience with phenformin timed disintegration capsules in Indian diabetics.
THE treatment of diabetes mellitus by oral drugs has found general acceptance. Phenformin hydrochloride with a mechanism of action different from that of the sulphonylureas, has been widely used in the Western countries during the last five years and has already acquired a reputation of being an effective drug in the treatment of primary or secondary failures to sulphonylureas and in the smooth...
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Since 1956 biguanides have received attention as oral hypoglycaemic agents (Krall and Bradley, 1959). Ungar, Madison, and Carter (1960), using phenformin (Dibotin, phenethyl biguanide), showed their effect on peripheral utilization of glucose, Butterfield, Fry, and Holling (1958) having previously demonstrated increased uptake of insulin in hepatic and peripheral tissues. Since then the drug ha...
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An investigation into B(12) absorption in diabetic patients on long-term phenformin therapy was undertaken and the results were compared to a similar investigation previously reported in diabetics on long-term metformin. Forty-six per cent of patients were found to have B(12) malabsorption as shown by abnormal results of Schilling tests.The mechanism of B(12) malabsorption is unknown but it is ...
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Cortisol to creatinine ratios in overnight urine samples, urinary glucose excretion, and plasma glucose concentrations were determined in 43 diabetic inpatients. All initially had normal cortisol to creatinine ratios (less than 55 x 10(-6)) and were initially treated by increasing their long-acting insulin component. Nine patients in whom this ratio became raised then had their long-acting insu...
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To evaluate the response during insulin-induced hypoglycemia, diabetics treated with relatively selective or nonselective beta-adrenergic blocking agents were studied. Placebo, atenolol (100 mg/day), and propranolol (80 mg b.i.d.) were administered to 12 insulin-treated diabetics for 1 week in a double-blind, randomized, crossover fashion with a 2-week washout between treatments. Sufficient int...
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ژورنال
عنوان ژورنال: BMJ
سال: 1972
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.5794.205